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KMID : 0385019990150010061
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 1 p.61 ~ p.66
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Significance of Major Histocompatibility Complex(MHC) Haplotype in the Development of Behcet´s Disease-like Symptom Induced by Herpes Simplex Virus in Several Inbred Mouse Strains
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손성향/Sohn, Seong Hyang
이은소/방동식/이성낙/Lee, Eun So/Bang, Dong Sik/Lee, Sung Nack
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Abstract
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It has been postulated that human leukocyte antigen (HLA)-B51 is associated with Behcet´s disease. We already induced Behcet´s disease-like symptom in ICR mice inoculated with herpes simples virus. In order to demonstrate the role of histocompatibility antigen in the development of Behcet´s diseaselike symptom, several inbred moose strains-B10.BR (H-2^k), B10.RI11 (H-2^r), Cb7BL/6 (H-2^b), C3H/He (H-2^k)which had different types of major or histocompatibility complex (MHC), were inoculated with herpes simples virus type 1 (KOS strain). Manifestations such as oral, genital, cutaneous ulcers, uveitis, and arthritis, that are considered clinically significant for the diagnosis of Behcet´s disease in patients appeared. By hematoxylin & eosin stain, inflammatory cells were accumulated around blood vessels in manifested skin tissues. HSV DNA was detected by polymerase chain reaction in akin lesions of B10.BR, B10.RIII and C67BL/6 strains. Behcet´s disease-like symptoms were developed in 40-60% of B10.BR, B10.RIII and C67BL/6 strains, but in only 2% of C3H/He. B10.BR and C3H/He strains had a common haplotype (H-2^k) but the rate of manifestation was different. 30, these results indicate that MHC is not directly correlated with the development of Behcet´s disease in the herpes simples virus induced animal models.
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KEYWORD
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